Posts Tagged ‘specific’

Aging Collection Marks First of Many Interdisciplinary Troves for Researchers

In the first of what will be a monthly series, SAGE Publishing will open up articles in a specific area of public interest – note, not in a specific discipline – to help researchers pursue knowledge outside of their usual silos. This month, SAGE (the parent of Social Science space) launched an interdisciplinary microsite on […]

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Origin and differentiation of human memory CD8 T cells after vaccination

The differentiation of human memory CD8 T cells is not well understood. Here we address this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity in humans. We used in vivo deuterium labelling to mark CD8 T cells that proliferated in response to the virus and then assessed cellular turnover and longevity by quantifying deuterium dilution kinetics in YFV-specific CD8 T cells using mass spectrometry. This longitudinal analysis showed that the memory pool originates from CD8 T cells that divided extensively during the first two weeks after infection and is maintained by quiescent cells that divide less than once every year (doubling time of over 450 days). Although these long-lived YFV-specific memory CD8 T cells did not express effector molecules, their epigenetic landscape resembled that of effector CD8 T cells. This open chromatin profile at effector genes was maintained in memory CD8 T cells isolated even a decade after vaccination, indicating that these cells retain an epigenetic fingerprint of their effector history and remain poised to respond rapidly upon re-exposure to the pathogen.

Share Your Research on a Blog

How can researchers provide information about their studies in ways that would be useful and interesting to prospective and current research participants? With that question in my mind, MethodSpace’s Janet Salmons began to explore the potential for blogs to recruit and inform participants. As with almost any online exploration, she discovered a much broader potential for blogs in the academic world.

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