Posts Tagged ‘outward’

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Gαsβγ protein determined by Volta phase-plate single-particle cryo-electron microscopy. The peptide agonist engages the receptor by binding to an extended hydrophobic pocket facilitated by the large outward movement of the extracellular ends of transmembrane helices 6 and 7. This conformation is accompanied by a 60° kink in helix 6 and a large outward movement of the intracellular end of this helix, opening the bundle to accommodate interactions with the α5-helix of Gαs. Also observed is an extended intracellular helix 8 that contributes to both receptor stability and functional G-protein coupling via an interaction with the Gβ subunit. This structure provides a new framework for understanding G-protein-coupled receptor function.

Hubble reveals ‘smoking gun’ in Eta Carinae mystery

New findings help rewrite the story of how the iconic and mysterious Eta Carinae star […]

The post Hubble reveals ‘smoking gun’ in Eta Carinae mystery appeared first on Futurity.

Dark Energy and Ockham’s razor

Ockham’s razor is the idea that, in trying to understand something, getting unnecessary information out of the way is the fastest way to the truth or to the best explanation. For example Einstein’s General Theory of Relativity is based on the relative simple concept of a curvature in a space-time metric.  Granted the math required […]

Powered by WordPress | Designed by: video game | Thanks to search engine optimization, seo agency and Privater Sicherheitsdienst