Posts Tagged ‘networks’

How babies learn to walk holds potential clues to autism

“Our findings may allow us to identify the brain regions and networks that can predict aspects of autism before it’s possible to make a clinical diagnosis.”

The GEO Handbook on Biodiversity Observation Networks

Recently published the GEO Handbook on Biodiversity Observation Networks presents a powerful resource that will provide valuable guidance to those committed to protecting, sustaining and preserving biodiversity across the planet. The practical exper…

Can ‘mood ring’ sensors warn before bridges fail?

Scientists are working with “mood ring” materials as a potential way to minimize and mitigate […]

The post Can ‘mood ring’ sensors warn before bridges fail? appeared first on Futurity.

Evolution of Osteocrin as an activity-regulated factor in the primate brain

Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity. These networks have primarily been studied in mice, and it is not known whether there are species- or clade-specific activity-regulated genes that control features of brain development and function. Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons. We find that OSTN has been repurposed in primates through the evolutionary acquisition of DNA regulatory elements that bind the activity-regulated transcription factor MEF2. In addition, we demonstrate that OSTN is expressed in primate neocortex and restricts activity-dependent dendritic growth in human neurons. These findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates.

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