Posts Tagged ‘movement’

Researchers discover why disturbed sleep hampers learning

It seems obvious that a poor night’s sleep would hamper a person’s ability to learn new skills or information, but now researchers from the University of Zurich and the Swiss Federal Institute of Technology have for the first time scientifically established a causal link between the two. While it had long been hypothesized that deep […]

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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Gαsβγ protein determined by Volta phase-plate single-particle cryo-electron microscopy. The peptide agonist engages the receptor by binding to an extended hydrophobic pocket facilitated by the large outward movement of the extracellular ends of transmembrane helices 6 and 7. This conformation is accompanied by a 60° kink in helix 6 and a large outward movement of the intracellular end of this helix, opening the bundle to accommodate interactions with the α5-helix of Gαs. Also observed is an extended intracellular helix 8 that contributes to both receptor stability and functional G-protein coupling via an interaction with the Gβ subunit. This structure provides a new framework for understanding G-protein-coupled receptor function.

Longitudinal quasi-static stability predicts changes in dog gait on rough terrain [RESEARCH ARTICLE]

Simon Wilshin, Michelle A. Reeve, G. Clark Haynes, Shai Revzen, Daniel E. Koditschek, and Andrew J. SpenceLegged animals utilize gait selection to move effectively and must re-cover from environmental perturbations. We show that on rough terrain domes…

Researchers in Japan just created a tiny, amoeba-inspired robot

A robot is movement, controlled. This is as true for plane-sized flying machines as it is for micrometer-sized contraptions, like the amoeba-inspired robot recently created by researchers at Japan’s Tohoku University. It isn’t the smallest robot ever m…

Time travel: is it possible?

Is time travel possible? The laws of physics in the microscopic world suggest that it is because the physical processes they define at the subatomic level appear to be either entirely or mostly time symmetric.  In other words the theoretical statements that describe them remain true if the direction of time is reversed.  However, the […]

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