Posts Tagged ‘Interact’

Share Your Research on a Blog

How can researchers provide information about their studies in ways that would be useful and interesting to prospective and current research participants? With that question in my mind, MethodSpace’s Janet Salmons began to explore the potential for blogs to recruit and inform participants. As with almost any online exploration, she discovered a much broader potential for blogs in the academic world.

The post Share Your Research on a Blog appeared first on Social Science Space.

The quantum properties of non-point particles

Quantum theory: it’s unreal We know that everything in the universe including particles have physical size. Even so for the past 50 years, the Standard Model of particle physics which many say has given us the most complete mathematical description of the particles and forces that shape our world ignores this fact and treats them […]

The post The quantum properties of non-point particles appeared first on The Imagineer's Chronicles.

Mechanism of super-assembly of respiratory complexes III and IV

Respiratory chain complexes can super-assemble into quaternary structures called supercomplexes that optimize cellular metabolism1. The interaction between complexes III (CIII) and IV (CIV) is modulated by supercomplex assembly factor 1 (SCAF1, also known as COX7A2l)2. The discovery of SCAF1 represented strong genetic evidence that supercomplexes exist in vivo2, 3. SCAF1 is present as a long isoform (113 amino acids) or a short isoform (111 amino acids) in different mouse strains2, 4. Only the long isoform can induce the superassembly of CIII and CIV2-6, but it is not clear whether SCAF1 is required for the formation of the respirasome (a supercomplex of CI, CIII2 and CIV)1,2,4-6. Here, by combining deep proteomics and immunodetection analysis, we show that SCAF1 is always required for the interaction between CIII and CIV and that the respirasome is absent from most tissues of animals harbouring the short isoform of SCAF1, with the exception of heart and skeletal muscle. We used directed mutagenesis to characterize SCAF1 regions that interact with CIII and CIV and discovered that this interaction requires the correct orientation of a histidine residue at position 73 that is altered in the short isoform of SCAF1, explaining its inability to interact with CIV. Furthermore, we found that the CIV subunit COX7A2 is replaced by SCAF1 in supercomplexes containing CIII and CIV and by COX7A1 in CIV dimers, and that dimers seemed to be more stable when they included COX6A2 rather than the COX6A1 isoform.

How and why space space and time interact.

Additionally defining or describing what time is extremely difficult. Some define it only in the abstract saying that is an invention of the human consciousness that gives us a sense of order, a before and after so to speak of the changes that occur in our environment.  However one can define or describe space in […]

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