Posts Tagged ‘Genetics’

Melinda Mills on Sociogenomics

Combining sociology and genetics, Melinda Mills and her collaborators abandon the nature v. nurture controversy for empirical research on family formation, inequality, child-rearing and other real-life concerns. In this Social Science Bites podcast, she discusses this new field of ‘sociogenomics.’

The post Melinda Mills on Sociogenomics appeared first on Social Science Space.

Epigenetics: Aeon writer says Darwin’s theory is “incomplete”

From Michael Skinner at Aeon: Darwin’s theory that natural selection drives evolution is incomplete without input from evolution’s anti-hero: Lamarck If sneers had weight, the Darwinian sneers against Lamarck over the last century or so would have crushed the Royal Society building to rubble. Let’s remember that when we hear bafflegab PR about how nothing […]

Can a trio of methods save American chestnuts?

Three methods for bringing American chestnut trees back to North American forests can now converge, […]

The post Can a trio of methods save American chestnuts? appeared first on Futurity.

Darwinian Christian racism? Election years bring dangerous creatures from the shadows

Darwinian Christian racism? Election years bring dangerous creatures from the shadows From Denyse O’Leary (O’Leary for News) at MercatorNet: Just recently, one Russell Kirk (probably a pseudonym*) blind-copied me on a post to “oxfordchristia” to advise me that Many younger Bible-centered conservative Christians have declared war on Christian Cultural Marxism. At first I thought, well, […]

Forward-genetics analysis of sleep in randomly mutagenized mice

Sleep is conserved from invertebrates to vertebrates, and is tightly regulated in a homeostatic manner. The molecular and cellular mechanisms that determine the amount of rapid eye movement sleep (REMS) and non-REMS (NREMS) remain unknown. Here we identify two dominant mutations that affect sleep and wakefulness by using an electroencephalogram/electromyogram-based screen of randomly mutagenized mice. A splicing mutation in the Sik3 protein kinase gene causes a profound decrease in total wake time, owing to an increase in inherent sleep need. Sleep deprivation affects phosphorylation of regulatory sites on the kinase, suggesting a role for SIK3 in the homeostatic regulation of sleep amount. Sik3 orthologues also regulate sleep in fruitflies and roundworms. A missense, gain-of-function mutation in the sodium leak channel NALCN reduces the total amount and episode duration of REMS, apparently by increasing the excitability of REMS-inhibiting neurons. Our results substantiate the use of a forward-genetics approach for studying sleep behaviours in mice, and demonstrate the role of SIK3 and NALCN in regulating the amount of NREMS and REMS, respectively.

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