Posts Tagged ‘energetic’

New technique could reveal the sneakiest black holes in the galaxy

While studying the molecular gas around a distant supernova remnant, researchers at Japan’s Keio University have discovered a new way to detected “quiet” black holes – those that don’t generate an accretion disk or which are not strong enough to emit visible radiation. According to Gizmodo and UPI reports, Keio graduate student Masaya Yamada and […]

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A cannabinoid link between mitochondria and memory

Cellular activity in the brain depends on the high energetic support provided by mitochondria, the cell organelles which use energy sources to generate ATP. Acute cannabinoid intoxication induces amnesia in humans and animals, and the activation of type-1 cannabinoid receptors present at brain mitochondria membranes (mtCB1) can directly alter mitochondrial energetic activity. Although the pathological impact of chronic mitochondrial dysfunctions in the brain is well established, the involvement of acute modulation of mitochondrial activity in high brain functions, including learning and memory, is unknown. Here, we show that acute cannabinoid-induced memory impairment in mice requires activation of hippocampal mtCB1 receptors. Genetic exclusion of CB1 receptors from hippocampal mitochondria prevents cannabinoid-induced reduction of mitochondrial mobility, synaptic transmission and memory formation. mtCB1 receptors signal through intra-mitochondrial Gαi protein activation and consequent inhibition of soluble-adenylyl cyclase (sAC). The resulting inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system eventually leads to decreased cellular respiration. Hippocampal inhibition of sAC activity or manipulation of intra-mitochondrial PKA signalling or phosphorylation of the Complex I subunit NDUFS2 inhibit bioenergetic and amnesic effects of cannabinoids. Thus, the G protein-coupled mtCB1 receptors regulate memory processes via modulation of mitochondrial energy metabolism. By directly linking mitochondrial activity to memory formation, these data reveal that bioenergetic processes are primary acute regulators of cognitive functions.

Comparative locomotor costs of domestic dogs reveal energetic economy of wolf-like breeds [RESEARCH ARTICLE]

C. M. Bryce and T. M. WilliamsThe broad diversity in morphology and geographic distribution of the 35 free-ranging members of the family Canidae is only rivaled by that of the domesticated dog, Canis lupus familiaris. Considered to be among nature’s mo…

Innovations and Techno-ecological Transition

  This book aims to present a systemic perspective to energetic transition to a discarbonated society implying an increase of energetic efficiency of current production process, new way of energy production – integration of renewable energ…

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