Posts Tagged ‘Endocrine’

Torturing the data till it really scares people

From Ronald Bailey at Reason: When environmental activists could no longer maintain with a straight face that exposure to trace amounts of synthetic chemicals is a significant cause for cancer in people, the endocrine disruption hypothesis was ginned up. The idea is that chemicals that mimic estrogen are causing epidemics of deformed penises, lower sperm […]

Scientists solve the mystery of the female orgasm

The evolutionary trait leading to the female orgasm began as a way to stimulate ovulation in early mammals, scientists from Yale University and the Cincinnati Children’s Hospital reported in new research published online Monday. Writing in the Journal of Experimental Zoology Part B Molecular and Developmental Evolution, Gunter Wagner, a professor of ecology and evolutionary […]

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Identification of proliferative and mature β-cells in the islets of Langerhans

Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential; understanding the mechanisms that underlie this functional heterogeneity might make it possible to develop new regenerative approaches. Here we show that Fltp (also known as Flattop and Cfap126), a Wnt/planar cell polarity (PCP) effector and reporter gene, acts as a marker gene that subdivides endocrine cells into two subpopulations and distinguishes proliferation-competent from mature β-cells with distinct molecular, physiological and ultrastructural features. Genetic lineage tracing revealed that endocrine subpopulations from Fltp-negative and -positive lineages react differently to physiological and pathological changes. The expression of Fltp increases when endocrine cells cluster together to form polarized and mature 3D islet mini-organs. We show that 3D architecture and Wnt/PCP ligands are sufficient to trigger β-cell maturation. By contrast, the Wnt/PCP effector Fltp is not necessary for β-cell development, proliferation or maturation. We conclude that 3D architecture and Wnt/PCP signalling underlie functional β-cell heterogeneity and induce β-cell maturation. The identification of Fltp as a marker for endocrine subpopulations sheds light on the molecular underpinnings of islet cell heterogeneity and plasticity and might enable targeting of endocrine subpopulations for the regeneration of functional β-cell mass in diabetic patients.

MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors

The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent.

Australian government caught spraying highly-dangerous, illegal chemicals on fragile wetlands

Australia is often reputed as having one of the most effective regulatory systems in the world for ensuring the safe use of chemicals. But it recently came to our attention that a regional government body in the state of Queensland has decided to devel…

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