Posts Tagged ‘deafness’

Why Deaf People Don’t Achoo When They Sneeze

You may not know it, but peer pressure influences what you sound like when you sneeze. Sneezing feels—and is—so involuntary, yet apparently you do still have some control over what you say when you sneeze. “Achoo!” is particular to English speaker…

Resveratrol in grapes and wine protects from deafness and Alzheimer’s

There’s new hope for a natural way to prevent two of the most dreaded conditions that most often hit elders – hearing loss and Alzheimer’s disease. According to a new study just published online ahead of print in the journal Otolaryngology-Head and Nec…

tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans

Transmembrane channel-like (TMC) genes encode a broadly conserved family of multipass integral membrane proteins in animals. Human TMC1 and TMC2 genes are linked to human deafness and required for hair-cell mechanotransduction; however, the molecular functions of these and other TMC proteins have not been determined. Here we show that the Caenorhabditis elegans tmc-1 gene encodes a sodium sensor that functions specifically in salt taste chemosensation. tmc-1 is expressed in the ASH polymodal avoidance neurons, where it is required for salt-evoked neuronal activity and behavioural avoidance of high concentrations of NaCl. However, tmc-1 has no effect on responses to other stimuli sensed by the ASH neurons including high osmolarity and chemical repellents, indicating a specific role in salt sensation. When expressed in mammalian cell culture, C. elegans TMC-1 generates a predominantly cationic conductance activated by high extracellular sodium but not by other cations or uncharged small molecules. Thus, TMC-1 is both necessary for salt sensation in vivo and sufficient to generate a sodium-sensitive channel in vitro, identifying it as a probable ionotropic sensory receptor.

MUTATION WITHIN THE CONNEXIN 26 GENE RESPONSIBLE FOR PRELINGUAL NON-SYNDROMIC DEAFNESS AND METHOD OF DETECTION

A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsibl…

Deafness

Some time ago I tried to gather articles to offer as a carnival on disability in science. I put quite a bit effort into finding material, but got few offers. It was a project I had wanted to do for some time and the lack of response was very disappoint…

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