Posts Tagged ‘Control’

How babies learn to walk holds potential clues to autism

“Our findings may allow us to identify the brain regions and networks that can predict aspects of autism before it’s possible to make a clinical diagnosis.”

Criminals are using drones to airdrop drugs and porn into prison

Amazon is experimenting with drone delivery in hopes to ship your impulse buys through the air, but a much seedier group seems to have already mastered the craft– much to the chagrin of law enforcement groups across the United States. According to a report published this weekend by USA Today, drones have been used on […]

The post Criminals are using drones to airdrop drugs and porn into prison appeared first on Redorbit.

Maternity leave catch-22: People see women as bad workers or bad moms

Women who take time off to care for their newborn children are believed to be less committed and less competent at work, while those who continued performing their job-related duties after the birth of their kids are considered to be less caring parents, according to a new study. “This is a no-win situation for women,” […]

The post Maternity leave catch-22: People see women as bad workers or bad moms appeared first on Redorbit.

Russian drone company teases real-life ‘hoverbike’

A Russian drone building company recently posted an online video teasing a single-seat ‘hoverbike’ that looks like a cross between a motorcycle and a quadcopter drone. Dubbed the Scorpion-3, the electric-powered flying vehicle was designed by engineers who wanted to make “an extreme sports instrument” for both “amateur and professional navigators,” the company said. According […]

The post Russian drone company teases real-life ‘hoverbike’ appeared first on Redorbit.

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome

Quality control mechanisms intervene appropriately when defective translation events occur, in order to preserve the integrity of protein synthesis. Rescue of ribosomes translating on messenger RNAs that lack stop codons is one of the co-translational quality control pathways. In many bacteria, ArfA recognizes stalled ribosomes and recruits the release factor RF2, which catalyses the termination of protein synthesis. Although an induced-fit mechanism of nonstop mRNA surveillance mediated by ArfA and RF2 has been reported, the molecular interaction between ArfA and RF2 in the ribosome that is responsible for the mechanism is unknown. Here we report an electron cryo-microscopy structure of ArfA and RF2 in complex with the 70S ribosome bound to a nonstop mRNA. The structure, which is consistent with our kinetic and biochemical data, reveals the molecular interactions that enable ArfA to specifically recruit RF2, not RF1, into the ribosome and to enable RF2 to release the truncated protein product in this co-translational quality control pathway. The positively charged C-terminal domain of ArfA anchors in the mRNA entry channel of the ribosome. Furthermore, binding of ArfA and RF2 induces conformational changes in the ribosomal decoding centre that are similar to those seen in other protein-involved decoding processes. Specific interactions between residues in the N-terminal domain of ArfA and RF2 help RF2 to adopt a catalytically competent conformation for peptide release. Our findings provide a framework for understanding recognition of the translational state of the ribosome by new proteins, and expand our knowledge of the decoding potential of the ribosome.

Powered by WordPress | Designed by: video game | Thanks to search engine optimization, seo agency and Privater Sicherheitsdienst