Archive for the ‘Chemistry’ Category

Information Retrieval and Text Mining Technologies for Chemistry

Chemical ReviewsDOI: 10.1021/acs.chemrev.6b00851

Cyclopropanation Strategies in Recent Total Syntheses

Chemical ReviewsDOI: 10.1021/acs.chemrev.6b00798

Materials science: Organic analogues of graphene

Chemists have long aspired to synthesize two-dimensional polymers that are fully conjugated — an attribute that imparts potentially useful properties. Just such a material has been prepared using a solid-state polymerization reaction.

Molybdenum chloride catalysts for Z-selective olefin metathesis reactions

The development of catalyst-controlled stereoselective olefin metathesis processes has been a pivotal recent advance in chemistry. The incorporation of appropriate ligands within complexes based on molybdenum, tungsten and ruthenium has led to reactivity and selectivity levels that were previously inaccessible. Here we show that molybdenum monoaryloxide chloride complexes furnish higher-energy (Z) isomers of trifluoromethyl-substituted alkenes through cross-metathesis reactions with the commercially available, inexpensive and typically inert Z-1,1,1,4,4,4-hexafluoro-2-butene. Furthermore, otherwise inefficient and non-stereoselective transformations with Z-1,2-dichloroethene and 1,2-dibromoethene can be effected with substantially improved efficiency and Z selectivity. The use of such molybdenum monoaryloxide chloride complexes enables the synthesis of representative biologically active molecules and trifluoromethyl analogues of medicinally relevant compounds. The origins of the activity and selectivity levels observed, which contradict previously proposed principles, are elucidated with the aid of density functional theory calculations.

Bicomponent Supramolecular Architectures at the Vacuum–Solid Interface

Chemical ReviewsDOI: 10.1021/acs.chemrev.6b00389

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