Archive for the ‘Biology & Nature’ Category

METHOD FOR PREDICTING ANTITUMOR EFFICACY OF HSP90 INHIBITOR IN CANCER TREATMENT

A method for determining sensitivity of a tumor to a HSP90 inhibitor, including: measuring a phosphorylation level of Akt or a phosphorylation level of ERK in a tissue of the tumor from a patient.

Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders

Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the ex…

METHODS AND KITS FOR DETECTING FUNGAL INFECTION

Methods and kits which utilize a conjugate, preferably an adduct, of ergosterol for determining the presence or level of a broad spectrum of ergosterol-containing organisms (e.g., fungi) in various substrates are disclosed. These methods and kits can b…

IMAGE CYTOMETER FOR CHARACTERIZATION AND QUANTIFICATION OF PARTICULATE SAMPLES

An image cytometer for capturing and analyzing the image of a sample in the momentum domain. The cytometer is provided with a light source for illuminating a sample with a light beam, an optical transforming system positioned behind the sample in the b…

MUTANT SMOOTHENED AND METHODS OF USING THE SAME

The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, we describe a mutation in the serpentine receptor, Smoothened (SMO), w…

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