Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Gαsβγ protein determined by Volta phase-plate single-particle cryo-electron microscopy. The peptide agonist engages the receptor by binding to an extended hydrophobic pocket facilitated by the large outward movement of the extracellular ends of transmembrane helices 6 and 7. This conformation is accompanied by a 60° kink in helix 6 and a large outward movement of the intracellular end of this helix, opening the bundle to accommodate interactions with the α5-helix of Gαs. Also observed is an extended intracellular helix 8 that contributes to both receptor stability and functional G-protein coupling via an interaction with the Gβ subunit. This structure provides a new framework for understanding G-protein-coupled receptor function.

Nature doi: 10.1038/nature22327

Africa: ‘The Ocean Is Not a Dumping Ground’

[IPS] Port-Louis -An internationally renowned scientist, Ameenah Gurib-Fakim became Mauritius's sixth president on June 5, 2015 - and one of the few Muslim women heads of state in the world.

EU Green Week 2017

EU Green Week 2017 will take place from 29 May to 2 June with the theme of 'Green jobs for a greener future'. It will focus on how EU environmental policies are creating green jobs and contributing to economic, sustainable and socially responsible growth in the EU. It will also highlight the demand for new types of green skills in many professional sectors.

In addition to a high level conference in Brussels, the programme will also feature a series of partner events and actions taking place across Europe. As well as being invited to take part in person, stakeholders and the general public are encouraged to become 'virtually' involved by participating in a wide range of on-line and social media activities.

More information is available here: http://www.eugreenweek.eu/

 


How Ideal Worker Norms Shape Work-Life for Different Constituent Groups in Higher Education: New Directions for Higher Education, Number 176


 

Work and family concerns are increasingly on the radar of colleges and universities. These concerns emerge out of workplace norms suggesting that for employees and students to be successful, they must be “ideal workers”.

This volume explores work norms in higher education, focusing on the ways that employees and students interpret and experience ideal worker expectations in light of family responsibilities. Chapters address how the ideal worker norms



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Large asteroid to hurtle past Earth on April 19

Paris (AFP) April 14, 2017
An asteroid as big as the Rock of Gibraltar will streak past Earth on April 19 at a safe but uncomfortably close distance, according to astronomers. "Although there is no possibility for the asteroid to collide with our planet, this will be a very close approach for an asteroid this size," NASA said in a statement. Dubbed 2014-JO25 and roughly 650 metres (2,000 feet) across, the asteroid
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